Status:
COMPLETED
Computed Tomography (CT) and Lung Function Data Collection for Computational Fluid Dynamics (CFD) in Chronic Obstructive Pulmonary Disease (COPD) Patients
Lead Sponsor:
University Hospital, Antwerp
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
In this study, 20 COPD patients will undergo a high-resolution/multi slice CT scan and lung function tests to obtain patient specific geometries of the central and peripheral small airways and patient...
Eligibility Criteria
Inclusion
- Patients with documented COPD based on the following criteria:
- Smoking history of at least 10 pack-years.
- Decreased Tiffeneau index (FEV1/(F)VC \< 0.70).
- Patients aged ≥ 40 years.
- Patients should present moderate to very severe COPD with an FEV1 \< 80% of predicted (GOLD 2, 3 and 4).
- Patients should be treated according to GOLD guidelines.
- Maintained on stable respiratory medications for 4 weeks prior to visit 1
- Able to perform lung function tests.
Exclusion
- Patients below the age of 40.
- Patients who are pregnant or are breast-feeding.
- A respiratory infection or exacerbation of COPD in the four weeks prior to screening.
- BMI \> 35 kg/m².
- Patients treated with BiPAP or CPAP.
- Known active tuberculosis.
- A history of asthma, cystic fibrosis, central bronchiectasis, interstitial lung disease or pulmonary thromboembolic disease.
- A history of thoracotomy with pulmonary resection.
- Active or untreated malignancy.
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2009
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00966459
Start Date
November 1 2008
End Date
May 1 2009
Last Update
September 1 2009
Active Locations (1)
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1
University Hospital Antwerp
Edegem, Antwerp, Belgium, 2650