Status:
COMPLETED
Study of Tumor and Blood Samples From Postmenopausal Women With Primary Breast Cancer Enrolled on Clinical Trial CAN-NCIC-MA27
Lead Sponsor:
Alliance for Clinical Trials in Oncology
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Breast Cancer
Eligibility:
FEMALE
45+ years
Brief Summary
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer....
Detailed Description
OBJECTIVES: Primary * To identify genetic variation, as measured by single nucleotide polymorphisms, that is associated with musculoskeletal adverse events in specimens from postmenopausal women wit...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically or cytologically confirmed invasive breast cancer
- Complete resection of primary tumor
- Stage I-III (T1-3, N0-3, M0) disease
- Enrolled in clinical trial CAN-NCIC-MA27.
- No locally recurrent or metastatic breast cancer
- Hormone receptor status:
- Estrogen receptor- or progesterone receptor-positive disease
- PATIENT CHARACTERISTICS:
- Postmenopausal status, defined as one of the following:
- At least 60 years old
- Age 45-59 years with spontaneous cessation of menses for \> 12 months prior to chemotherapy or study randomization
- Age 45-59 years with cessation of menses for \< 12 months or secondary to hysterectomy AND a follicle-stimulating hormone (FSH) level in the postmenopausal range (or \> 34.4 IU/L)
- Age 45-59 years on hormone replacement therapy (HRT) and discontinued HRT at diagnosis of breast cancer AND FSH level in the postmenopausal range (or \> 34.4 IU/L)
- Bilateral oophorectomy
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Exclusion
Key Trial Info
Start Date :
September 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2018
Estimated Enrollment :
364 Patients enrolled
Trial Details
Trial ID
NCT00968214
Start Date
September 1 2008
End Date
September 1 2018
Last Update
February 21 2020
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