Status:
COMPLETED
Muscle Mass During Space Exploration
Lead Sponsor:
The University of Texas Medical Branch, Galveston
Collaborating Sponsors:
National Space Biomedical Research Institute
Conditions:
Muscle Loss
Eligibility:
All Genders
45-60 years
Phase:
NA
Brief Summary
The investigators will test the following hypotheses: 1. Bedrest will blunt the anabolic response to a mixed nutrient meal, facilitating a loss of muscle mass and functional capacity that is only par...
Detailed Description
Our long-term goal is to identify, prevent and remedy defects in the metabolic pathway that contribute to the loss of muscle mass and function during exposure to microgravity. Demographic data indicat...
Eligibility Criteria
Inclusion
- Age between 45-60
- Ability to sign informed consent
Exclusion
- Subjects with cardiac abnormalities considered exclusionary by the study physicians
- Subjects with uncontrolled metabolic disease
- A GFR \<65 mL/min/1.73m2 or evidence of kidney disease or failure
- Subjects with vascular disease or risk factors of peripheral atherosclerosis
- Any history of hypo- or hyper-coagulation disorders. (e.g., Coumadin use or history of DVT or PE)
- Subjects with chronically elevated systolic pressure \>150 or a diastolic blood pressure \> 100
- Subjects with implanted electronic devices (e.g., pacemakers, electronic infusion pumps, stimulators)
- Subjects with recently (6 months) treated cancer other than basal cell carcinoma
- Any subject currently on a weight-loss diet or a body mass index \> 30 kg/m2
- Inability to abstain from smoking for duration of study
- A history of \> 20 pack per year smoking
- Any subject that is HIV-seropositive or has active hepatitis
- Recent anabolic or corticosteroids use (within 3 months)
- Subjects with hemoglobin or hematocrit lower than accepted lab values
- Agitation/aggression disorder
- History of stroke with motor disability
- A recent history (\<12 months) of GI bleed
- Any other condition or event considered exclusionary by the PI and faculty physician
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2015
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00968344
Start Date
August 1 2009
End Date
April 1 2015
Last Update
May 31 2019
Active Locations (1)
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1
The University of Texas Medical Branch
Galveston, Texas, United States, 77555