Status:
COMPLETED
Galantamine Effects on Cognitive Function in Marijuana Users
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
US Department of Veterans Affairs
Conditions:
Memory
Eligibility:
All Genders
18-55 years
Phase:
PHASE1
Brief Summary
To evaluate galantamine's effects on cognitive performance in marijuana users. Galantamine, an acetylcholine esterase inhibitor, is approved for treatment of Alzheimer's disease. Current marijuana use...
Detailed Description
To summarize, marijuana users show impaired cognitive functioning, especially in working memory and verbal learning and memory functions. Impaired cognitive functioning predicts poor treatment respons...
Eligibility Criteria
Inclusion
- Men and women between the ages of 18 and 55 who are dependent on or abuse marijuana, according to DSM-IV criteria;
- History of marijuana use on the average of at least twice a week over a one-month period;
- Current marijuana use, indicated by positive urine toxicology for marijuana;
- No current medical problems and normal ECG;
- For women, neither pregnant as determined by pregnancy screening nor breast feeding, and using acceptable birth control methods.
Exclusion
- Current major psychiatric illnesses including mood, psychotic, or anxiety disorders;
- Current dependence to other drugs of abuse or alcohol (except nicotine or marijuana dependence);
- History of major medical illnesses including asthma or chronic obstructive lung disease, history or current gastrointestinal ulcer, hepatic or renal impairment and cardiac rhythm disturbances or other medical conditions that the study physician deems contraindicated for the subject to be in the study;
- Use of other medications including a) drugs that slow heart rate (eg, beta-blockers),which may increase the risk of bradycardia and AV block and b) NSAIDs; increased potential for developing ulcers/active or occult gastrointestinal bleeding;
- Known allergy to galantamine
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT00969696
Start Date
August 1 2009
End Date
July 1 2011
Last Update
July 25 2012
Active Locations (1)
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1
Department of Veterans Affairs
West Haven, Connecticut, United States, 06516