Status:

COMPLETED

Mechanism of Insulin-Resistant in Lean Non-Diabetics

Lead Sponsor:

University of California, San Francisco

Conditions:

Insulin Resistance

Insulin Sensitivity

Eligibility:

All Genders

20-50 years

Phase:

PHASE1

Brief Summary

The study is designed to test the following primary hypothesis: * Aerobic exercise training will improve insulin sensitivity in insulin resistant subjects through changes in the major cellular signal...

Eligibility Criteria

Inclusion

  • Men and women aged 20-50
  • No regular exercise for past 2 years

Exclusion

  • Diabetes, Cardiovascular disease, Pregnant or lactating females,BMI \>27
  • Medications that may interfere with carbohydrate metabolism - glucocorticoids, adrenergic agonists, ACE inhibitors, alpha blockers, diuretics, beta blockers, oral contraceptives, HMG CoA reductase inhibitors
  • History of epilepsy, cancer, hepatitis, active infection, active Graves' disease, cystic fibrosis, sickle cell anemia, peripheral vascular disease, cerebrovascular disease, asthma
  • Any medical condition that in the opinion of the investigator will interfere with safe completion of the trial
  • Inability to give informed consent
  • Prior participation in a clinical trial that could potentially alter insulin sensitivity: e.g., use of new insulin sensitizers
  • HIV seropositive
  • Anemia (Hgb \< 12 g/dl)

Key Trial Info

Start Date :

February 1 2004

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

December 1 2009

Estimated Enrollment :

149 Patients enrolled

Trial Details

Trial ID

NCT00970099

Start Date

February 1 2004

End Date

December 1 2009

Last Update

January 23 2014

Active Locations (1)

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1

Ucsf Gcrc

San Francisco, California, United States, 94143