Status:
COMPLETED
A Comparison of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) and System of Supportive Psychotherapy (SYSP) for Early Onset Chronic Depression
Lead Sponsor:
University Hospital Freiburg
Conditions:
Chronic Major Depressive Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of this study is to compare the efficacy of the Cognitive Behavioural Analysis System of Psychotherapy (CBASP) with the non-specific System of Supportive Psychotherapy (SYSP)in early onset...
Detailed Description
Effective treatment strategies for chronic depression are urgently needed since it is not only a common and particularly disabling disorder, but is also considered treatment resistant by most clinicia...
Eligibility Criteria
Inclusion
- DSM-IV criteria for a current episode of chronic MDD, MDD superimposed on a pre-existing dysthymic disorder or recurrent MDD with incomplete remission between episodes in a patient with a current MDD and a total duration of at least 2 years.
- Early onset of the disorder according to DSM-IV (onset before the age of 21)
- Age between 18 and 65
- A score of at least 20 on the 24-item HRSD at screening and, after a 2-week drug-free period, at baseline
- Fluent in German language
- Provide informed consent
Exclusion
- Acute risk for suicide (as opposed to suicidal thoughts) assessed according to clinical practice guidelines. Suicidal patients are eligible, as long as outpatient treatment is deemed safe by the clinician.
- A history of psychotic symptoms, bipolar disorder, or organic brain disorders
- A primary diagnosis of another axis I disorder including anxiety disorders (e.g. Posttraumatic Stress Disorder), or any severe substance-related abuse or dependence disorder as evaluated with the SCID-I
- Antisocial, schizotypical, or borderline personality disorder (SCID-II);
- Severe cognitive impairment
- Absence of a response to previous adequate trial of CBASP, and/or SYSP
- Other ongoing psychotherapy or medication
- A serious medical condition (i.e. a history of seizures, severe head trauma, stroke or heart attack within six months before the study began)
Key Trial Info
Start Date :
April 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
268 Patients enrolled
Trial Details
Trial ID
NCT00970437
Start Date
April 1 2010
End Date
December 1 2014
Last Update
July 5 2017
Active Locations (1)
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1
University Medical Center Freiburg, Department of Psychiatry and Psychotherapy
Freiburg im Breisgau, Germany, 79104