Status:
COMPLETED
Age, Lifestyle, Muscle Mechanisms in Insulin Resistance
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Obesity
Glucose Intolerance
Eligibility:
MALE
50+ years
Phase:
NA
Brief Summary
The purpose of this study is to investigate the mechanisms by which physical inactivity and obesity alter skeletal muscle insulin signaling to cause insulin resistance and increase the development of ...
Detailed Description
Aging is associated with a progressive development of impaired glucose tolerance (IGT), due to an increased peripheral tissue resistance to the action of insulin. Insulin resistance, a common state in...
Eligibility Criteria
Inclusion
- Men older than 50 yrs of age
- Non-smoking (more than 5 years)
- BMI greater than 25 kg/m2 and less than 50 kg/m2
Exclusion
- CAD, CHF, Myocardial infarction within 6 months or other symptomatic heart disease
- History of stroke, peripheral arterial disease
- Currently being treated for active cancer
- On oral agents or insulin therapy for diabetes
- Poorly controlled Dyslipidemia (abnormal concentration of lipids or lipoproteins in the blood)
- Poorly controlled hypertension (BP \> 180/95)
- Other systematic disorders that are not medically treated and stable
- Physical impairment limiting normal activity and other contraindications to exercise
- Aerobically conditioned
- Abnormal response to exercise (chest pain, significant arrhythmias, extreme shortness of breath, cyanosis, exercising BP \> 240/120)
- Taking warfarin/coumadin
- Taking oral steroids
- Abnormal renal function or liver function
- Chronic pulmonary disease severe enough to require oxygen
- Anemia
- MMSE \< 24, dementia
Key Trial Info
Start Date :
June 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2008
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00971594
Start Date
June 1 2004
End Date
May 1 2008
Last Update
September 3 2009
Active Locations (2)
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1
Baltimore VA Medical Center
Baltimore, Maryland, United States, 21201
2
University of Maryland
Baltimore, Maryland, United States, 21201