Status:
COMPLETED
Blood Flow Responses to an Oral Glucose Tolerance Test in Type 2 Diabetes
Lead Sponsor:
University of Kansas Medical Center
Collaborating Sponsors:
US Department of Veterans Affairs
Conditions:
Type 2 Diabetes
Insulin Resistance
Eligibility:
All Genders
30-65 years
Phase:
NA
Brief Summary
The investigators wish to determine whether a short period of exercise training (5-10 days) improves the metabolic and cardiovascular response of people with or at risk of developing type 2 diabetes t...
Detailed Description
Insulin resistance is characterized by decreased sensitivity to the metabolic actions of insulin (glucose disposal) and is a hallmark of obesity and type 2 diabetes (T2D). Insulin resistance is also a...
Eligibility Criteria
Inclusion
- Insulin resistant: diagnosed with pre-diabetes or fasting blood glucose \>/= 100 mg/dL
- T2D: diagnosed by primary care physician
- BMI: less than 43 kg/m2
- Age: 30-65
Exclusion
- Smoking
- Insulin use (other than once daily)
- Underlying conditions that limit ability to exercise safely
- Recent weight gain or loss (\> 5% of body weight in 3 months)
- Physically active (\> 30 min aerobic exercise, 2 d/wk)
- Recent (\< 3 mo) changes in medication use or dose
- Uncontrolled T2D (HbA1c \> 10%)
- Advanced retinopathy or neuropathy
- Pregnancy
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00972452
Start Date
August 1 2009
End Date
September 1 2010
Last Update
September 24 2015
Active Locations (1)
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1
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160