Status:
COMPLETED
Changing Thought and Action in Tobacco Dependence With Transcranial Magnetic Stimulation
Lead Sponsor:
University of Arkansas
Conditions:
Tobacco Dependence
Eligibility:
All Genders
19-55 years
Phase:
NA
Brief Summary
This study will examine the effects of high frequency, repetitive Transcranial Magnetic Stimulation (rTMS) on decision-making and smoking behavior.
Detailed Description
Tobacco use is the greatest cause of preventable death in the US and cigarette smokers exhibit substantial relapse following treatment. Understanding the brain mechanisms involved in tobacco dependenc...
Eligibility Criteria
Inclusion
- Age 19-55
- Must speak English
- Must be right handed
- Must pass the Transcranial Magnetic Stimulation Adult Safety and Screening Questionnaire (TAAS)
- Smoking participants must be highly dependent with a score of 6 or greater on the Fagerstrom Test for Nicotine Dependence
Exclusion
- Positive test for drugs of abuse
- Positive pregnancy test
- A personal or family history of epilepsy
- A history of anticonvulsant medication use
- A personal history of head injury
- A history of aneurysm, stroke, or previous cranial neurosurgery
- A diagnosis of bipolar disorder
- A neurological or psychiatric disorder for which hospitalization was required
- Tinnitus
- Metal implants in the head, neck or cochlea
- A pacemaker
- Migraines
- A history of taking medications that lower seizure threshold (i.e. such as tricyclic antidepressants or bupropion)
- Claustrophobia (due to the MRI)
- Used any form of tobacco in the past two years if they desire to be a non-smoking participant
- Plans to quit smoking in the next 30 days if they desire to be a smoking participant
- Current use of any medications for tobacco cessation (i.e. nicotine replacement, bupropion, varenicline, etc.)
- A report of a high motivation to quit smoking (score 7 or great on the Motivation scale)
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT00973622
Start Date
October 1 2009
End Date
January 1 2012
Last Update
September 24 2013
Active Locations (1)
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1
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205