Status:
COMPLETED
Pathophysiological Mechanisms of Dyspnea and Activity-limitation in Mild Chronic Obstructive Pulmonary Disease (COPD)
Lead Sponsor:
Queen's University
Collaborating Sponsors:
Canadian Lung Association
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
Chronic obstructive pulmonary disease (COPD) is a growing cause of death, disability and health care costs in Canada. Nevertheless, COPD remains largely under-diagnosed and under-treated, particularly...
Eligibility Criteria
Inclusion
- Post-bronchodilator forced expiratory volume in 1 sec (FEV1) ≥ 80%predicted and a FEV1/forced vital capacity (FVC) ratio \< 0.70;
- Clinically stable as defined by no changes in medication dosage or frequency of administration with no exacerbations or hospitalizations in the preceding 6 weeks;
- A cigarette smoking history ≥ 20 pack-yrs;
- Body mass index between 18.5 and 30 kg/m2;
- Able to perform all study procedures and provide informed consent.
Exclusion
- A diffusing capacity of the lung for carbon monoxide (DLCO) \< 40 %predicted;
- Presence of active cardiopulmonary disease (or comorbidities) other than COPD that could contribute to dyspnea and exercise limitation;
- Clinical diagnosis of sleep disordered breathing;
- History or clinical evidence of asthma;
- Presence of important contraindications to clinical exercise testing, including inability to exercise because of neuromuscular or musculoskeletal disease(s);
- Use of daytime oxygen or exercise-induced arterial oxygen desaturation to \<80% on room air.
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00975403
Start Date
October 1 2010
End Date
September 1 2012
Last Update
December 17 2012
Active Locations (1)
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1
Respiratory Investigation Unit, Kingston General Hospital
Kingston, Ontario, Canada, K7L 2V7