Status:
SUSPENDED
Pressure-Controlled vs Volume-Controlled Ventilation During One Lung Ventilation
Lead Sponsor:
King Faisal University
Conditions:
Thoracic Surgery
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Compared with the information available in sepsis and trauma-associated ARDS, less is known about the cause and pattern of lung injury after thoracic surgery. Definition of lung injury in this context...
Detailed Description
Project Objectives: We hypothesize that the use of PCV during OLV for thoracic surgery may improve the anti-inflammatory immunoregulation than VCV. It may attenuate the increases in proinflammatory c...
Eligibility Criteria
Inclusion
- Patients aged 18-60 years (ASA physical status II-III) scheduled for elective open thoracic surgery using one lung ventilation for periods longer than 1.5 h
Exclusion
- We will exclude the patients with:
- decompensated cardiac (\>New York Heart Association II)
- pulmonary diseases (VC or FEV1\<50% of the predicted values)
- pulmonary hypertension (mean pulmonary artery pressure \[MPAP\] \>30 mm Hg)
- previous lobectomy or bilobectomy in the medical history
- those treated with immune modulators (cytostatic drugs, corticosteroids and non-steroidal anti-inflammatory drugs, vaccination, blood products), within 3 months before surgery and with symptoms of an acute inflammatory process (clinically defined or abnormal data for C-reactive protein, leukocyte count, or body temperature)
Key Trial Info
Start Date :
May 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2023
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00975468
Start Date
May 1 2021
End Date
July 1 2023
Last Update
September 2 2020
Active Locations (1)
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1
King Fahd Hospital of the University
Dammam, Eastern Province, Saudi Arabia