Status:
COMPLETED
The Effect of Uric Acid Decrement on Endothelial Function in Patients With Chronic Renal Failure
Lead Sponsor:
Istanbul University
Conditions:
Hyperuricemia
Chronic Kidney Disease
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
In this prospective study, the investigators aimed to evaluate the effects of improved hyperuricemia, a minor cardiovascular risk factor, on endothelial dysfunction in patients with chronic kidney dis...
Detailed Description
Endothelial dysfunction (ED) is a key event in the development of atherosclerotic cardiovascular disease observed in patients with chronic kidney disease (CKD). Experimental models have shown that hyp...
Eligibility Criteria
Inclusion
- Laboratory finding of hyperuricemia
- Patients between ages of 18 and 60 years
- Non-diabetic patients
- Creatinine clearance values between 20 and 60 mL/min/1.73 m2
Exclusion
- Low (\< 20 ml/min/1.73 m2) creatinine clearance,
- Patients with diabetes mellitus, ischemic heart disease, acute coronary syndrome, congestive heart failure (CHF) (New York Heart Association class II or greater), valvular heart disease and a history of cerebral infarction or transient ischemic attack.
- Patients taking urate lowering medication (allopurinol and probenecid)
Key Trial Info
Start Date :
April 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2009
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00978653
Start Date
April 1 2008
End Date
May 1 2009
Last Update
September 22 2009
Active Locations (1)
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1
Istanbul Faculty of Medicine
Istanbul, Turkey (Türkiye), 34390