Status:
COMPLETED
The Effect of Ketamine on Interleukin-6 Synthesis in Hepatic Resections Requiring Temporary Porto-arterial Occlusion
Lead Sponsor:
Hospital Italiano de Buenos Aires
Conditions:
Hepatectomy
Eligibility:
All Genders
21+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether ketamine is effective to inhibit interleukin 6 synthesis in hepatic resections requiring temporary porto-arterial occlusion.
Detailed Description
Introduction: Many complications in liver resection surgery, such as post-operative hepatic insufficiency, sepsis, and multi-organ liver failure, have been attributed to ischemia-reperfusion injury an...
Eligibility Criteria
Inclusion
- Age: 21 or older
- Planned liver resection with Pringle maneuver lasting 30-60 minutes
Exclusion
- Chronic illness requiring corticosteroids
- Cirrhosis
- Hemodynamic instability prior to surgery
- Diabetes
- Sepsis
- Surgical interventions or chemotherapy treatments within the past 30 days
- Pregnancy
- Illnesses that could potentially affect the hepatic circulation
- Arterial hypertension
- Ocular hypertension
- Allergy to ketamine
- Preoperative portal embolization
- Radiofrequency ablation
- Patients requiring emergency surgeries
Key Trial Info
Start Date :
June 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2008
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT00978757
Start Date
June 1 2001
End Date
June 1 2008
Last Update
January 15 2019
Active Locations (1)
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1
Hospital Italiano de Buenos Aires
Buenos Aires, Argentina, 1181