Status:
TERMINATED
Fluorine F 18 EF5 PET/CT Imaging in Patients With Locally Advanced or Recurrent/Metastatic Cervical Cancer
Lead Sponsor:
Abramson Cancer Center at Penn Medicine
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Cervical Cancer
Eligibility:
FEMALE
18-120 years
Phase:
NA
Brief Summary
RATIONALE: Diagnostic procedures, such as fluorine F 18 EF5 PET/CT imaging, may help find oxygen in tumor cells. It may also help doctors predict a patient's response to treatment and help plan the be...
Detailed Description
OBJECTIVES: * To determine if the presence and heterogeneity of hypoxia can be detected by fluorine F 18 EF5 binding in tumors during PET/CT imaging in patients with newly diagnosed or recurrent carc...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Diagnosis of carcinoma of the cervix meeting 1 of the following criteria:
- Pathologically confirmed, newly diagnosed stage IB-IVA (locally advanced) disease
- Imaging evidence of recurrent or metastatic disease
- Measurable disease, defined as ≥ 1 cm on anatomic imaging
- PATIENT CHARACTERISTICS:
- Karnofsky performance status 70-100%
- WBC \> 2,000/mm³
- Platelet count \> 90,000/mm³
- Total bilirubin \< 2.0 mg/dL
- Creatinine \< 2.0 mg/dL
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No history of allergic reactions attributed to Flagyl (metronidazole)
- No other condition or personal circumstance that, in the judgment of the Investigator, may interfere with the collection of complete, good-quality data
- PRIOR CONCURRENT THERAPY:
- Not specified
Exclusion
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 4 2013
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00978874
Start Date
May 1 2008
End Date
September 4 2013
Last Update
June 25 2021
Active Locations (1)
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1
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104-4283