Status:
COMPLETED
Study of the Immunoresponse in Patients Treated With a Tyrosine Kinase Inhibitor
Lead Sponsor:
Radboud University Medical Center
Conditions:
Renal Cell Carcinoma
GIST
Eligibility:
All Genders
18+ years
Brief Summary
In this study the researchers investigate the influence of the tyrosine kinase inhibitors sunitinib and sorafenib, on the normal humoral and cellular immuno response to influenza vaccination in patien...
Detailed Description
When cure is not longer possible, cancer patients enter the palliative phase. For many types of cancer several treatment options are available. The goal of this treatment is to prolong survival, but m...
Eligibility Criteria
Inclusion
- Patients with metastasized renal cell carcinoma or GIST who have been treated with sunitinib or sorafenib for at least 4 weeks, or patients with metastasized RCC who did not receive a systemic treatment for their RCC (nephrectomy is allowed)
- Patients who are indicated for influenza vaccination and and have been summoned for this vaccination by their GP
- age ≥18 years (for the healthy volunteers: age≥ 60 years)
- signed Informed Consent Form
Exclusion
- patients with an identified immunodeficiency disorder
- patients that have been treated with corticosteroids in the past 2 weeks or who are still using these (except for a short period \<10 days)
- patients that are treated with immunotherapy in the last year (ex. interferon-alpha of IL-2) or who have received another form of targeted therapy (ex. bevacizumab).
- patients with symptoms of influenza at the time of vaccination
- patient with an allergy for chicken-eggwhite
Key Trial Info
Start Date :
October 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2009
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT00979381
Start Date
October 1 2008
End Date
November 1 2009
Last Update
March 18 2010
Active Locations (1)
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1
University Medical Center Nijmegen st Radboud
Nijmegen, Netherlands, 6525 GH