Status:
COMPLETED
Blood Antioxidant Status in Chronic Hepatitis C Patients Before and After Antioxidant Supplementation: a Randomized Clinical Trial
Lead Sponsor:
Universidade do Sul de Santa Catarina
Conditions:
Hepatitis C
Oxidative Stress
Eligibility:
All Genders
20-60 years
Phase:
NA
Brief Summary
The objective of the present study is to evaluate the antioxidant status in the blood of HCV patients treated with pegylated interferon (2a 1.5 ug/kg; 2b 180 ug) combined with ribavirin (1000 to 1250 ...
Detailed Description
The WHO estimated that around 170 million people are infected by HCV, about 3% of the world population. HCV is the leading cause of acute hepatitis and chronic liver disease, which may lead to cirrhos...
Eligibility Criteria
Inclusion
- without the presence of illnesses associated with systemic diseases, no chronic alcoholism, without HIV coinfection, and were not participating in other studies.
- Patients with hepatitis C were selected according to the Clinical Protocol and Guidelines for Therapeutic Hepatitis C Viral.
- Group I - All subjects were negative for HCV, HBV, HIV, HBsAg, anti-HBc total, anti-HCV and normal serum transaminases.
Exclusion
- Patients with one of the following laboratory abnormalities were also excluded: leukocytes, neutrophils, platelets, serum creatinine 1.5 times upper limit of normal, elevated thyroid stimulating hormone, alpha-fetoprotein above normal limits, and/or focal lesion on ultrasound performed within 1 month of study entry.
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2009
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00983164
Start Date
January 1 2007
End Date
April 1 2009
Last Update
September 23 2009
Active Locations (3)
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1
Hospital Nereu Ramos
Florianópolis, Santa Catarina, Brazil
2
Hospital Universitário Universidade Federal Santa Catarina
Florianópolis, Santa Catarina, Brazil
3
Policlínica II
Florianópolis, Santa Catarina, Brazil