Status:
TERMINATED
Phase 2 Total Skin Electron Beam Therapy (TSEBT 12 Gy) in Stage IB-IIIA Mycosis Fungoides
Lead Sponsor:
Stanford University
Conditions:
Mycosis Fungoides
Lymphomas: Non-Hodgkin
Eligibility:
All Genders
18+ years
Brief Summary
To examine the efficacy and safety of total skin electron beam therapy to a dose of 12 Gray (TSEBT 12 Gy) in patients who have mycosis fungoides (MF) staged as IB to IIIA.
Detailed Description
Total skin electron beam therapy will be administered in the Department of Radiation Oncology according to the Stanford six-field technique. Patients will receive a planned total skin dose of 12 Gy fr...
Eligibility Criteria
Inclusion
- Biopsy-confirmed mycosis fungoides in stage IB-IIIA
- 2\. Patients must have failed or have been intolerant to at least one prior systemic or topical therapy which may include topical steroids
- 3\. 18 years of age or older
- 4\. Life expectancy greater than 6 months
- 5\. Eastern Cooperative Oncology Group (ECOG) of \<= 2
- 6\. Adequate bone marrow function: WBC\> 2000/uL; platelet count\> 75,000/mm3; ANC\> 1000
- 7\. Required wash out period for prior therapies (Note: patients with progressive disease may be treated earlier than required washout period per Investigator's decision)
- Topical therapy: 2 weeks
- Systemic biologic, monoclonal antibody or chemotherapy: 4 weeks
- Radiotherapy (excluding TSEBT) or phototherapy: 4 weeks
- Other investigational therapy: 4 weeks
- 8\. Ability to understand and the willingness to sign a written informed consent document.
Exclusion
- Prior courses of TSEBT (Note: localized skin-directed radiotherapy is allowed if administered at least 4 weeks prior to initiation on study)
- 2\. Underlying medical condition including unstable cardiac disease, or other serious illness that would impair the ability of patient to undergo treatment
- 3\. Prior malignancy (active within 5 years of screening) except completely excised non-invasive basal cell or squamous cell carcinoma of the skin, or in situ squamous cell carcinoma of the cervix
- 4\. Pregnant or lactating
- 5\. Initiation or change in dosage of topical corticosteroids within 3 weeks of study treatment (Note: topical steroid use within 3 weeks is allowed provided the strength and use has been stable for at least 1 month; "prescription strength"topical corticosteroids cannot be started during the study)
- 6\. Any other medical history, including laboratory results, deemed by the Investigator to be likely to interfere with patient participation in the study
Key Trial Info
Start Date :
June 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2012
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT00985140
Start Date
June 1 2009
End Date
May 1 2012
Last Update
June 2 2017
Active Locations (1)
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1
Stanford University School of Medicine
Stanford, California, United States, 94305