Status:
COMPLETED
Specialized Radiation Therapy in Treating Patients With Stage II, Stage III, Stage IV, or Recurrent Non-Small Cell Lung Cancer and Poor Performance Status
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Lung Cancer
Eligibility:
All Genders
18-120 years
Phase:
PHASE1
Brief Summary
RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. PURPOSE: This phase I trial is ...
Detailed Description
OBJECTIVES: Primary * To escalate the dose of accelerated hypofractionated image-guided conformal radiotherapy to a potent tumoricidal dose without exceeding the maximum-tolerated dose in patients w...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically or cytologically confirmed non-small cell lung cancer
- Stage II-IV and/or recurrent disease
- No small cell histology
- Measurable or evaluable disease
- Tumor not amenable to surgical resection
- Tumor not eligible for stereotactic body radiation therapy
- No prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
- PATIENT CHARACTERISTICS:
- Zubrod performance status 2-4
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must agree to use effective contraception
- Must complete all required pretreatment evaluations
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- More than 1 week since prior chemotherapy or chemoradiation therapy
- No concurrent chemotherapy
- No other concurrent antineoplastic therapy (including standard-fractionated radiotherapy to the chest, chemotherapy, biological therapy, vaccine therapy, and surgery) 1 week before, during, and for 1 week after completion of study therapy
Exclusion
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00986297
Start Date
October 1 2009
Last Update
August 20 2020
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Stanford University
Stanford, California, United States, 94305
2
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390