Status:
COMPLETED
Efficacy of Fluoxetine in Reducing Ictal Hypoventilation in Patients With Partial Epilepsy
Lead Sponsor:
University of California, Davis
Conditions:
Uncontrolled Partial Epilepsy
Ictal Hypoventilation
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of this study is to determine the effects of fluoxetine on breathing mechanisms during seizures. Patients with partial epilepsy commonly have changes in their breathing mechanisms during s...
Detailed Description
Patients who consent to participate in the study will come to the clinic one week prior to the scheduled date of hospitalization in the Epilepsy Monitoring Unit (EMU). At this visit a complete physica...
Eligibility Criteria
Inclusion
- Adult patients with temporal lobe epilepsy, aged 18-65.
- Medical intractability of seizures such that VET to determine candidacy for epilepsy surgery is determined to be clinically appropriate for the patient by the primary treating epileptologist.
- Intelligence Quotient \>70.
- Native English speaker or adequate fluency in English to provide informed consent.
- Female patients of child-bearing potential must be using an acceptable method of contraception, including abstinence.
Exclusion
- Progressive neurological disease.
- Severe depression, bipolar disease or psychosis.
- History of suicidal ideation or intent.
- Clinically significant concurrent medical illness, including hepatic or renal insufficiency and diabetes.
- Pregnant or lactating women.
- Current heavy alcohol or illicit drug use.
- Patients already taking fluoxetine or other selective serotonin reuptake inhibitors (SSRIs).
- Concurrent use of monoaminoxidase inhibitors, antipsychotic agents, antidepressant agents other than SSRIs or frequent use of triptan agents.
- History of a previous allergic reaction or adverse effects with SSRIs.
- History of serotonin syndrome.
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT00986310
Start Date
August 1 2009
End Date
June 1 2012
Last Update
November 27 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of California, Davis
Sacramento, California, United States, 95817