Status:
COMPLETED
Oocyte Cryopreservation Comparing Fresh and Vitrified Sibling Oocytes
Lead Sponsor:
UConn Health
Collaborating Sponsors:
EMD Serono
Conditions:
Infertility
Eligibility:
FEMALE
21-37 years
Brief Summary
Vitrification is a method to cryopreserve biological specimens that are sensitive to chilling injury such as oocytes and embryos, and it has been employed with increased survival rate and live births ...
Detailed Description
The necessity to cryopreserve human oocytes successfully, with the goal of achieving term pregnancies at rates equivalent to those obtained with fresh oocytes is urgent. Cryopreservation of oocytes is...
Eligibility Criteria
Inclusion
- Females 21 to 37 years of age.
- Normal serum follicle stimulating hormone (FSH) concentration \<10 mIU/ml and estradiol (E2) concentration \<70 pg/ml obtained on day #2 or 3 of the menstrual cycle.
- BMI \< 35.
- No physical or gynecological abnormalities (including major uterine surgery) constituting a medical contraindication to embryo transfer and pregnancy including any known significant genetic disorders
- Non-smoker for at least 3 months prior to study enrollment.
- Normal antral follicle count (total ≥ 10).
Exclusion
- Greater than 1 previous miscarriage.
- More than 1 previous failed IVF attempt.
- Previous poor response to ovarian stimulation (peak E2 level \<1,000 pg/ml or \< 4 oocytes retrieved).
- Presence of untreated hydrosalpinx.
- Stage III or IV endometriosis.
- Intent to have preimplantation genetic diagnosis (PGD) of embryos
- Unwillingness to freeze or inseminate all eligible oocytes or embryos.
- Male partner requiring surgical sperm retrieval (MESA or TESA).
Key Trial Info
Start Date :
August 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2013
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT00986687
Start Date
August 1 2009
End Date
February 1 2013
Last Update
December 3 2015
Active Locations (1)
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1
The Center for Advanced Reproductive Services
Farmington, Connecticut, United States, 06030-6224