Status:
COMPLETED
Myocardial Oedema in Acute Myocardial Infarction (AMI)
Lead Sponsor:
Barts & The London NHS Trust
Conditions:
Myocardial Infarction
Eligibility:
All Genders
18+ years
Brief Summary
Despite recent improvements in treatment, myocardial infarction (heart attack) is still a leading cause of illness and death in the UK. Following the acute event, it is difficult to predict which pati...
Eligibility Criteria
Inclusion
- Patients presenting to the London Chest Hospital with acute ST elevation myocardial infarction and treated with primary angioplasty and stent implantation within 12 hours of symptom onset
- Acute PCI / stent implantation has been successful (residual stenosis visually \< 30% and TIMI flow ≥ 2)
- At the time of inclusion, the patient no longer requires intravenous catecholamines or mechanical hemodynamic support (aortic balloon pump)
- Serum troponin \>1ng/ml 12 hours after onset of pain
- The patient is able to give written informed consent
- The patient must be able to understand and communicate in English
Exclusion
- Known cardiomyopathy
- Previous documented myocardial infarction
- Previous percutaneous coronary intervention or coronary artery bypass surgery
- Significant renal dysfunction (EGFR\<30)
- Systemic steroid therapy
- Current non steroidal anti-inflammatory drug use
- Chronic inflammatory disease
- Neoplastic disease without documented remission within the past 5 years
- Pregnancy
- Reduced mental capacity leading to inability to obtain informed consent
- Participation in another clinical trial within the last 30 days
Key Trial Info
Start Date :
November 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2011
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00987259
Start Date
November 1 2009
End Date
October 1 2011
Last Update
February 1 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The London Chest Hospital
London, Greater London, United Kingdom, E2 9JX