Procalcitonin Guided Versus Conventional Antibiotic Therapy in Patients With Sepsis in the ICU

Status:

WITHDRAWN

Procalcitonin Guided Versus Conventional Antibiotic Therapy in Patients With Sepsis in the ICU

Lead Sponsor:

Rijnstate Hospital

Collaborating Sponsors:

Stichting Vrienden van het Alysis Leerhuis

Conditions:

Sepsis

Intensive Care

Eligibility:

All Genders

18+ years

Phase:

Brief Summary

The adequacy of early empiric antimicrobial therapy is an important factor in determining the outcome in patients with severe sepsis. The duration of adequate antibiotic therapy in these patients howe...

Eligibility Criteria

Inclusion

Patients admitted to the ICU
Age \> 18 years
Antibiotic therapy for sepsis with a suspected or proven focus of infection

Exclusion

Age \< 18 years
Pregnancy
Infection or presumed infection requiring prolonged antibiotic therapy (osteomyelitis, meningitis, endocarditis, septic arthritis, mediastinitis, tuberculosis, Pneumocystis jiroveci pneumonia, Toxoplasmosis, Legionellosis, Listeriosis)
Indication for prolonged systemic prophylactic antibiotic therapy
Severe viral or parasitic infections (hemorrhagic fever, malaria)
Antibiotic therapy started 48 hours before enrollment
Severe immunocompromised patients (AIDS with a CD4 count \< 200cells/mm3, severe neutropenia(\<500 neutrophils/mm3), patients undergoing immunosuppressive therapy after solid organ transplantation)
Patients foregoing life sustaining treatment

Key Trial Info

Start Date :

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

Estimated Enrollment :

Patients enrolled

Trial Details

Trial ID

NCT00987818

Last Update

September 2 2015

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