Status:
UNKNOWN
Endoscopy Every 2 Years or Only as Needed in Monitoring Patients With Barrett Esophagus
Lead Sponsor:
Gloucestershire Hospitals NHS Foundation Trust
Conditions:
Esophageal Cancer
Precancerous Condition
Eligibility:
All Genders
18-120 years
Phase:
NA
Brief Summary
RATIONALE: Screening tests may help doctors find cancer cells early and plan better treatment. It is not yet known whether endoscopy every 2 years is more effective than endoscopy only as needed in fi...
Detailed Description
OBJECTIVES: Primary * To establish whether endoscopic surveillance every 2 years or endoscopy at need only is superior in terms of overall survival and, if neither is superior, whether endoscopy at ...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically confirmed circumferential Barrett metaplasia meeting 1 of the following criteria:
- At least 1 cm from the gastro-esophageal junction
- At least a 2 cm non-circumferential tongue of Barrett metaplasia
- Undergone endoscopy within the last 2 years to confirm Barrett metaplasia and exclude high-grade dysplasia and carcinoma
- No known high-grade dysplasia or carcinoma
- PATIENT CHARACTERISTICS:
- Resident of the United Kingdom
- Informed of the risk of Barrett esophagus developing into esophageal cancer, either at the visit when the invitation letter is issued or on a documented previous occasion
- Able to undergo endoscopy
- No medical conditions that would make endoscopy difficult or hazardous
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Exclusion
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2022
Estimated Enrollment :
3400 Patients enrolled
Trial Details
Trial ID
NCT00987857
Start Date
March 1 2009
End Date
May 1 2022
Last Update
August 22 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Gloucestershire Royal Hospital
Gloucester, England, United Kingdom, GL1 3NN