Status:
COMPLETED
Mediterranean Diet and the Metabolic Syndrome
Lead Sponsor:
Laval University
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Cardiovascular Disease
Eligibility:
MALE
18-65 years
Phase:
NA
Brief Summary
While there is now undisputable evidence relating elevated plasma low-density lipoprotein (LDL) cholesterol levels to an increased risk of coronary heart disease (CHD), it is being increasingly recogn...
Detailed Description
The study has a duration of 35 weeks for each participant. Subjects will be first assigned to a North American control diet that they will consume for five weeks under isocaloric, weight-maintaining c...
Eligibility Criteria
Inclusion
- Men from the Québec City metropolitan area with the metabolic syndrome based on the NCEP-ATP III definition (3 criteria or more see below):
- Waist circumference ≥ 102 cm
- Triglycerides ≥ 1.7 mmol/L
- HDL-cholesterol \<= 1.04 mmol/L
- Systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg
- Fasting blood glucose ≥ 5.6 mmol/L
- Stable body weight (+/- 2 kg) for 6 months before the beginning of the study
Exclusion
- Previous history of cardiovascular disease, type 2 diabetes and monogenic dyslipidemia
- Subjects taking medications for hyperlipidemia or hypertension
- Endocrine disorders
- Food allergies or aversion for specific components of the MedDiet
- Smokers
- Consummation excessive of alcohol (\> 2 consummation/day)
Key Trial Info
Start Date :
May 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT00988650
Start Date
May 1 2007
End Date
December 1 2008
Last Update
March 5 2013
Active Locations (1)
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1
Institute of Nutraceutical and Functional Foods (INAF), Laval University
Québec, Quebec, Canada, G1V 0A6