Status:
UNKNOWN
Myocardial Protection With Perhexiline in Left Ventricular Hypertrophy
Lead Sponsor:
University Hospital Birmingham
Collaborating Sponsors:
University of Birmingham
Brighton and Sussex University Hospitals NHS Trust
Conditions:
Myocardial Reperfusion Injury
Cardiac Output, Low
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Open-heart surgery causes injury of the heart muscle. Although this is usually mild, temporary and reversible, if it is severe it can endanger life and require additional high cost care. During surger...
Eligibility Criteria
Inclusion
- Adult
- First-time
- Aortic valve surgery for aortic stenosis +/- coronary artery bypass
Exclusion
- Diabetes Mellitus
- Renal impairment with Creatinine greater than or equal to 200micromol/L
- Atrial fibrillation
- Amiodarone therapy, recent (in last month) or current
- Hepatic impairment, significant preoperative
- Peripheral neuropathy
- Pregnancy or breast-feeding
- Emergency surgery or required on clinical grounds within 5 days of referral
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2012
Estimated Enrollment :
220 Patients enrolled
Trial Details
Trial ID
NCT00989508
Start Date
October 1 2009
End Date
December 1 2012
Last Update
August 11 2011
Active Locations (1)
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1
University Hospital Birmingham
Birmingham, West Midlands, United Kingdom, B15 2TH