Status:
COMPLETED
Atherosclerosis in Rheumatoid Arthritis
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Rheumatoid Arthritis
Endothelial Dysfunction
Eligibility:
All Genders
18-80 years
Brief Summary
The purpose of this study is to investigate the link between rheumatoid arthritis and cardiovascular disease by studying inflammation, joint disease, cholesterol abnormalities, and endothelial functio...
Detailed Description
In the general population, individuals with elevated inflammatory markers (e.g. C-reactive protein, CRP) have increased cardiovascular disease. Patients with RA have chronic elevations in CRP and othe...
Eligibility Criteria
Inclusion
- Diagnosis of RA by ACR criteria
- Age 18-80
- Enrolled in UCSF RA cohort already
Exclusion
- Diabetes (on meds or in medical history)
- Pregnant or Lactating
- Renal failure (Creatinine \> 2mg/dL or on dialysis)
- History of MI or CAD
- History of ischemic CVA
- Symptomatic PVD
- Current uncontrolled hypertension (blood pressure \> 160/100mmHg)
- Daily prednisone \> 10mg daily
- Current smoker
- New BP med within 3 months
- New statin within 3 months
- Change in RA meds: new or increase in prednisone within 1 month, new TNF inhibitor within 2 months, titration of methotrexate, leflunomide or sulfasalazine within 3 months.
Key Trial Info
Start Date :
September 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00990730
Start Date
September 1 2009
End Date
June 1 2011
Last Update
January 25 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
UCSF San Francisco General Hospital Vascular Research Center
San Francisco, California, United States, 94110