Status:
TERMINATED
Magnetic Resonance Imaging (MRI) in the Assessment of Head and Neck Squamous Cell Carcinoma (HNSCC) Response
Lead Sponsor:
OHSU Knight Cancer Institute
Collaborating Sponsors:
Medical Research Foundation, Oregon
Radiological Society of North America
Conditions:
Head and Neck Cancer
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to see if new techniques of measuring HNSCC tumors with magnetic resonance imaging (MRI) can help predict how well the tumors will respond to combined chemotherapy and rad...
Detailed Description
DCE-MRI, DW-MRI, MRS have the potential to measure early cellular changes that occur in response to successful therapies, such as chemoradiation, and have been demonstrated to be early predictors not ...
Eligibility Criteria
Inclusion
- Histologically confirmed diagnosis of loco-regionally advanced (stage III or IV) squamous cell carcinoma of the head and neck (oropharynx, hypopharynx and larynx)
- Age \> 18 years
- No prior surgery, chemotherapy or radiation therapy for head and neck cancer
- Scheduled to receive chemoradiation for definitive therapy
Exclusion
- Contraindications to MRI (pacemaker, aneurysm clip, mechanical and/or electrical device or metallic fragment, severe claustrophobia)
- Contraindications to gadolinium
- Severe, active co-morbidity
- Major medical illnesses or psychiatric impairments
- Pregnant or nursing women
Key Trial Info
Start Date :
October 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2015
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00994201
Start Date
October 1 2011
End Date
June 1 2015
Last Update
March 25 2016
Active Locations (1)
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1
Oregon Health and Science University
Portland, Oregon, United States, 97239-3098