Status:
COMPLETED
The Effect of Esomeprazole and Fundoplication on Airways
Lead Sponsor:
Tampere University Hospital
Conditions:
Airway Responsiveness
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Evaluate the prevalence of bronchial responsiveness (BHR) among patients with gastroesophageal reflux disease (GERD). Investigate correlation between bronchial reactivity and the severity of GERD, an...
Eligibility Criteria
Inclusion
- Over 18 of age
- Diagnosis of gastroesophageal reflux disease
- Compliance to perform methacholine inhalation challenge (judged by the investigator)
Exclusion
- Known allergy to esomeprazole or any other PPI
- Use of systemic corticosteroids within 3 weeks before any study visit
- Pregnancy (in a written informed consent patients are asked to assure that they are not pregnant and they are also told to immediately stop the study medication if they become pregnant during the study)
- Incapability to keep a 3-week washout with usual antireflux medication prior to the first visit
- Regular use of PPI or H2-RA medication 3 months after fundoplication
Key Trial Info
Start Date :
December 1 2004
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00994708
Start Date
December 1 2004
Last Update
October 14 2009
Active Locations (1)
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1
Tampere University Hospital
Tampere, Pirkanmaa, Finland, 33521