Status:
TERMINATED
The Effects of Corticosteroids, Glucose Control, and Depth-of-Anesthesia on Perioperative Inflammation and Morbidity From Major Non-cardiac Surgery (Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT Trial))
Lead Sponsor:
d sessler
Conditions:
Inflammation
Perioperative Morbidity
Eligibility:
All Genders
40-90 years
Phase:
NA
Brief Summary
Evidence thus suggests that steroid administration, tight glucose control, and avoidance of deep anesthesia may decrease perioperative morbidity by reducing the inflammatory response to surgery. Using...
Detailed Description
The perioperative period is characterized by an intense inflammatory response marked by elevated concentrations of inflammatory markers like C-Reactive Protein (CRP). This response has been linked to ...
Eligibility Criteria
Inclusion
- Age ≥40 years old.
- Major non-cardiac surgical procedures scheduled to take ≥ two hours done under general anesthesia.
- Written informed consent
Exclusion
- Recent intravenous or oral steroid therapy (within 30 days); inhaled steroids are permitted
- Any contraindications to the proposed interventions
- ASA Physical Status \> 4
- Non English speaking patients
- Procedures done under regional anesthesia
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
381 Patients enrolled
Trial Details
Trial ID
NCT00995501
Start Date
January 1 2007
End Date
December 1 2015
Last Update
April 25 2017
Active Locations (1)
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1
Cleveland Clinic
Cleveland, Ohio, United States, 44195