Status:
COMPLETED
Terlipressin in Septic Shock: Effects on Microcirculation
Lead Sponsor:
University of Roma La Sapienza
Conditions:
Septic Shock
Sepsis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
The present study was conducted as a prospective, randomized study to investigate the effects of vasopressin receptor agonists terlipressin and vasopressin on systemic hemodynamics and microcirculatio...
Detailed Description
60 septic shock patients requiring norepinephrine to maintain mean arterial pressure between 65 and 75 mmHg despite adequate volume resuscitation will be enrolled in the study. After an initial hemody...
Eligibility Criteria
Inclusion
- Clinical diagnosis of septic shock
- Vasopressor support to maintain mean arterial pressure (MAP) between 65 and 75 mmHg despite adequate volume resuscitation (pulmonary artery occlusion pressure = 13-18 mmHg and central venous pressure = 8-12 mmHg)
Exclusion
- Pregnancy
- Age \< 18 years
- Present or suspected acute mesenteric ischemia
- Vasospastic diathesis (e.g. Raynaud's syndrome or related diseases)
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00995839
Start Date
November 1 2008
End Date
February 1 2010
Last Update
February 4 2010
Active Locations (1)
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1
Departement of Anesthesiology and Intensive Care
Rome, I, Italy, 00161