Status:
ACTIVE_NOT_RECRUITING
Genomic Structural Variation in Cancer Susceptibility
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Collaborating Sponsors:
Cold Spring Harbor Laboratory
Coriell Institute
Conditions:
Breast Cancer
Colon Cancer
Eligibility:
All Genders
Brief Summary
This study will look for new types of gene changes that may be related to cancer in some patients. Some gene changes (mutations) are passed on from parents to offspring (child). Other gene changes are...
Eligibility Criteria
Inclusion
- Proband must have living unaffected biologic mother and father available and eligible for participation in the study with one of the following (both incident and prevalent cases will be collected):
- Colorectal cancer diagnosed at or under the age of 50.
- Breast cancer diagnosed at or under the age of 45.
- Germ cell tumor diagnosed at or under the age of 40.
- Pediatric cancer of any type diagnosed at or under the age of 21
- Adult cancer or pre-neoplastic condition of any type diagnosed at or under the age of 40
- Cancer at any age in 2 or more siblings suggestive of a genetic etiology, such as brothers with testicular germ cell tumor or sisters with breast cancer and ovarian cancer
- Parents:
- Must be the biologic mother and biologic father of affected proband.
- Must have (by self-report) no history of cancer other than non-melanomatous skin cancer or cervical cancer in situ except in the case of inclusion criteria #6..
- In certain clinical situations, parent(s) with cancer may be included at the discretion of the Principal Investigator, if the Principal Investigator deems that the etiology of cancer in the parent(s) and proband are biologically unrelated.
- Sibling(s):
- Must be age 18 or older and have same biologic parents as proband.
Exclusion
- Known genetic mutation in proband or a family history that is indicative of hereditary cancer susceptibility.
Key Trial Info
Start Date :
October 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2026
Estimated Enrollment :
1275 Patients enrolled
Trial Details
Trial ID
NCT00996710
Start Date
October 1 2009
End Date
October 1 2026
Last Update
November 4 2025
Active Locations (1)
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1
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065