Status:
COMPLETED
Early Detection of Diastolic Dysfunction and the Role of Lifestyle Measures in Its Treatment
Lead Sponsor:
University of Missouri-Columbia
Conditions:
Diastolic Dysfunction
Eligibility:
All Genders
40-65 years
Phase:
NA
Brief Summary
The project aims to investigate the effect of a regular exercise for 6 months on diastolic parameters in patients who present with shortness of breath and who have evidence of early diastolic dysfunct...
Detailed Description
Introduction: Diastolic dysfunction (DD) accounts for \>50% of all heart failure (DHF) hospitalizations and this number is increasing with age, obesity and diabetes. There are no proven treatments f...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients with dyspnea/shortness of breath
- Age 40-65 years of age
- Sedentary lifestyle (\<150 minutes of exercise/week)
- Echocardiographic evidence of early diastolic dysfunction: mitral E/A \<0.9, OR resting E/E' between 8-15 cm/s, OR post-exercise E/E' \>13 cm/s.
- Exclusion criteria:
- Age \<40 years or \>65 years
- Coronary Artery Disease by angiography or evidence of ischemia on a stress test
- Systolic Dysfunction (LV Ejection fraction \<50%)
- Congestive Heart Failure Functional Class III or IV
- Moderate to severe COPD (FEV \<80% predicted)
- Moderate to severe valvular heart disease, except tricuspid regurgitation
- Inability to get heart rate \>/= 85% of maximum predicted heart rate
- Uncontrolled hypertension (systolic BP\>140mmHg, diastolic BP\>90mmHg) despite medical therapy
- On echocardiogram, RV systolic pressure \>60mmHg that suggests severe pulmonary hypertension
- On echocardiogram, left atrial size\> 6.5 cm or left atrial volume \> 35 ml/BSA
Exclusion
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2011
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT00998114
Start Date
June 1 2008
End Date
May 1 2011
Last Update
October 5 2016
Active Locations (1)
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1
Harry S Truman Veterans Administration Hospital
Columbia, Missouri, United States, 65201