Status:
COMPLETED
resVida and Fat Oxidation
Lead Sponsor:
Maastricht University Medical Center
Collaborating Sponsors:
DSM Nutritional Products, Inc.
Top Institute Food and Nutrition
Conditions:
Obesity
Eligibility:
MALE
45-65 years
Phase:
NA
Brief Summary
There is now a general consensus that the combination of excessive energy intake and a low capacity to oxidize fat will lead to muscular fat accumulation and insulin resistance. It is known for many y...
Eligibility Criteria
Inclusion
- male sex
- age 45-65 years
- body fat percentage \> 25%, BMI 30-35 kg/m2
- sedentary
- stable dietary habits
- willingness to abstain from ingestion of resveratrol-containing foods
- healthy
Exclusion
- female sex
- unstable body weight (weight gain or loss \> 3 kg in the last three months)
- total body fat percentage \< 25%
- fasting plasma glucose \> 6.1 mmol/l
- hemoglobin \< 7.8 mmol/l
- engagement in programmed exercise \> 2 hours total per week
- impaired kidney and/ or liver function
- first- or second-degree family member with type 2 diabetes mellitus
- any medical condition requiring treatment and/ or medication use
- intake of dietary supplements except vitamins and minerals
- unwilling to restrict high-resveratrol containing foods
- current alcohol consumption \> 20 grams/day
- participation in another biomedical study within 1 month before the screening visit
- a contraindication to MRI scanning. These contraindications include patients with the following devices:
- central nervous system aneurysm clips
- implanted neural stimulator
- implanted cardiac pacemaker or defibrillator
- cochlear implant
- insulin pump
- or metal containing corpora aliena in the eye or brains
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2011
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00998504
Start Date
October 1 2009
End Date
January 1 2011
Last Update
March 18 2011
Active Locations (1)
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1
Maastricht University Medical Center
Maastricht, Limburg, Netherlands, 6200 MD