Status:
COMPLETED
Nebivolol Versus Metoprolol: Comparative Effects on Fatigue and Quality of Life
Lead Sponsor:
Weill Medical College of Cornell University
Collaborating Sponsors:
Forest Laboratories
Conditions:
Hypertension
Eligibility:
All Genders
21-80 years
Phase:
PHASE4
Brief Summary
Beta-blockers are prescribed to millions of people for treatment of hypertension. Fatigue is a recognized and common side effect of beta-blockers that can have significant effects on quality of life. ...
Detailed Description
* Hypothesis: the beta-blocker nebivolol is associated with less fatigue than metoprolol, the most widely-prescribed beta-blocker * Methods: a double-blinded crossover trial comparing nebivolol with m...
Eligibility Criteria
Inclusion
- Individuals who are taking, or are about to begin taking, a beta-blocker, and who have the approved indication of hypertension
Exclusion
- Orthopedic ailments that would interfere with performance of treadmill testing
- Stroke or heart attack within the previous 1 year
- Symptomatic coronary disease within the past year (angina, shortness of breath)
- Clinically significant pulmonary disease (e.g. emphysema or asthma).
- Poorly controlled hypertension (blood pressure above 160 systolic or 100 diastolic)
- Patients with contra-indications to taking a beta-blocker (asthma or bradyarrhythmia)
- History of tachyarrhythmia (abnormal rapid heart rate)
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2011
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT00999102
Start Date
October 1 2009
End Date
January 1 2011
Last Update
October 19 2018
Active Locations (1)
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1
Weill Cornell Medical College
New York, New York, United States, 10065