Status:
COMPLETED
Shanghai Parkinson's Study
Lead Sponsor:
National Institute of Environmental Health Sciences (NIEHS)
Conditions:
Parkinson's Disease
Eligibility:
FEMALE
40-70 years
Brief Summary
Background: * Parkinson disease (PD) is the second most prevalent neurodegenerative disease, affecting more than 1 percent of the elderly population in the United States and other Western countries. ...
Detailed Description
We propose to clinically examine self-reported Parkinson s disease (PD) patients from the well established Shanghai Women s Health Study (SWHS) and thus initiate a long-term PD research in this unique...
Eligibility Criteria
Inclusion
- Inclusion and exclusion criteria:
- This study will be conducted within the infrastructure of the Shanghai Women s Health Study. At this stage, all self-reported PD cases through the 4th follow-up will be invited. As the 4th follow-up is ongoing, we will start with cases identified from the first three follow-ups and add new cases as they are identified. Through the 3rd follow-up, a total of 220 PD patients have self-identified and 141 are incident. Assuming 200 cases are still alive at the time of the proposed study and another 80 are self-identified during the 4th follow-up, we will have approximately 280 self-reported PD patients that are eligible for the clinical confirmation at current stage. Cases identified from future SWHS follow-ups will be eligible for future SPS work.
- Analyses on biomarkers and genes will be conducted in a case-control manner. Overall, two controls will be selected for each case, individually matched on year of birth (+/-1), and maybe some other factors such as survival status, baseline menopausal status, fasting status, season of specimen collection, and time of the day of specimen collection. These controls have provided exposure data and/or biospecimen at baseline. Therefore at current stage no active field data collection will be carried out for controls.
- As at the current stage, the expected number of Parkinson cases is small, therefore we do not plan to pre-exclude any participants from this study.
Exclusion
Key Trial Info
Start Date :
October 14 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 25 2018
Estimated Enrollment :
149 Patients enrolled
Trial Details
Trial ID
NCT00999388
Start Date
October 14 2009
End Date
January 25 2018
Last Update
April 5 2018
Active Locations (2)
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1
Fudan University Huashan Hospital Shanghai
Shanghai, China, 200040
2
Shanghai Cancer Institute
Shanghai, China