Status:
ACTIVE_NOT_RECRUITING
Safety and Efficacy Study in Subjects With Leber Congenital Amaurosis
Lead Sponsor:
Spark Therapeutics, Inc.
Collaborating Sponsors:
Children's Hospital of Philadelphia
University of Iowa
Conditions:
Inherited Retinal Dystrophy Due to RPE65 Mutations
Leber Congenital Amaurosis
Eligibility:
All Genders
3+ years
Phase:
PHASE3
Brief Summary
The study is a Phase 3, open-label, randomized controlled trial of gene therapy intervention by subretinal administration of AAV2-hRPE65v2 (voretigene neparvovec-rzyl). At least twenty-four subjects, ...
Detailed Description
Leber congenital amaurosis (LCA) is a disease where part of the eye (the retina) is severely diseased. Usually it is detected in affected people within the first few months of life, as there is signif...
Eligibility Criteria
Inclusion
- Willingness to adhere to protocol and long-term follow-up as evidenced by written informed consent or parental permission and subject assent (where applicable).
- Diagnosis of LCA due to RPE65 mutations; molecular diagnosis is to be performed, or confirmed, by a CLIA-approved laboratory.
- Age three years old or older.
- Visual acuity worse than 20/60 (both eyes) and/or visual field less than 20 degrees in any meridian as measured by a III4e isopter or equivalent (both eyes).
- Sufficient viable retinal cells as determined by non-invasive means, such as optical coherence tomography (OCT) and/or ophthalmoscopy. Must have either: 1) an area of retina within the posterior pole of \>100 µm thickness shown on OCT; 2) ≥ 3 disc areas of retina without atrophy or pigmentary degeneration within the posterior pole; or 3) remaining visual field within 30 degrees of fixation as measured by a III4e isopter or equivalent.
- Subjects must be evaluable on mobility testing (the primary efficacy endpoint) to be eligible for the study. Evaluable is defined as: 1) The ability to perform mobility testing within the luminance range evaluated in the study. Individuals must receive an accuracy score of ≤ 1 during screening mobility testing at 400 lux or less to be eligible; individuals with an accuracy score of \> 1 on all screening mobility test runs at 400 lux, or those who refuse to perform mobility testing at screening, will be excluded. 2) The inability to pass mobility testing at 1 lux. Individuals must fail screening mobility testing at 1 lux to be eligible; individuals that pass one or more screening mobility test runs at 1 lux will be excluded.
Exclusion
- Unable or unwilling to meet requirements of the study, including receiving bilateral subretinal vector administrations.
- Any prior participation in a study in which a gene therapy vector was administered.
- Participation in a clinical study with an investigational drug in the past six months.
- Use of retinoid compounds or precursors that could potentially interact with the biochemical activity of the RPE65 enzyme; individuals who discontinue use of these compounds for 18 months may become eligible.
- Prior intraocular surgery within six months.
- Known sensitivity to medications planned for use in the peri-operative period.
- Pre-existing eye conditions or complicating systemic diseases that would preclude the planned surgery or interfere with the interpretation of study. Complicating systemic diseases would include those in which the disease itself, or the treatment for the disease, can alter ocular function. Examples are malignancies whose treatment could affect central nervous system function (for example: radiation treatment of the orbit; leukemia with CNS/optic nerve involvement). Subjects with diabetes or sickle cell disease would be excluded if they had any manifestation of advanced retinopathy (e.g., macular edema or proliferative changes). Also excluded would be subjects with immunodeficiency (acquired or congenital) as there could be susceptibility to opportunistic infection (such as CMV retinitis).
- Individuals of childbearing potential who are pregnant or unwilling to use effective contraception for four months following vector administration.
- Individuals incapable of performing mobility testing (the primary efficacy endpoint) for reason other than poor vision, including physical or attentional limitations.
- Any other condition that would not allow the potential subject to complete follow-up examinations during the course of the study or, in the opinion of the investigator, makes the potential subject unsuitable for the study.
- Subjects will not be excluded based on their gender, race, or ethnicity.
Key Trial Info
Start Date :
October 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2030
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT00999609
Start Date
October 1 2012
End Date
January 1 2030
Last Update
April 23 2025
Active Locations (2)
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1
University of Iowa
Iowa City, Iowa, United States, 52242
2
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104