Status:
COMPLETED
Acute Fatty Acid Intervention Study (AFAST)
Lead Sponsor:
Wageningen University
Collaborating Sponsors:
Dutch Dairy Organization (NZO)
Conditions:
Cardiovascular Disease
The Metabolic Syndrome
Eligibility:
MALE
18-30 years
Phase:
NA
Brief Summary
The main objective of this study is to elucidate whether different dietary fatty acids (SFA, PUFA, butter fat and margarine fat) in a high fat load will have different effects on PBMC gene expression ...
Detailed Description
Nutrition plays a key role in the development of metabolic disorders like cardiovascular disease and the metabolic syndrome. Nutrients that can contribute to the risk of developing such diseases are f...
Eligibility Criteria
Inclusion
- Healthy Caucasian men
- age between 18 and 30 years
Exclusion
- Allergic to fish oil
- Allergic to margarine
- Allergic to cow milk or dairy products
- Current or recent (\<4 weeks) use of fish oil supplements or more then four times fish/week; 24.35 g of EPA-DHA of fish per month (800 mg/day) as judged by the questionnaire.
- Body mass index (BMI) \< 18 or \> 25 kg/m2
- Urine glucose concentrations outside normal ranges (low to non-detectable)
- Fasting blood glucose outside the normal range (3 - 5.5 mmol/L)
- Tobacco smoking
- Taking medication that may influence the study results
- Received inoculations within 2 months of starting the study or planned to during the study
- Donated or intended to donate blood from 2 months before the study till two months after the study
- Diagnosed with any long-term medical condition (eg., diabetes, hemophilia, cardiovascular disease, anemia, gastrointestinal disease)
- Vegetarian
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2008
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT01000194
Start Date
January 1 2008
End Date
March 1 2008
Last Update
October 22 2009
Active Locations (1)
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1
Wageningen University
Wageningen, Gelderland, Netherlands, 6700 AH