Status:
COMPLETED
Immune Suppression and Ventilator Associated Pneumonias
Lead Sponsor:
Matthew Exline
Conditions:
Sepsis
Eligibility:
All Genders
18+ years
Brief Summary
Patients in the ICU are already predisposed to nosocomial infections, which are both costly and potentially life threatening, and it appears that the immune paralysis of sepsis may put these patients ...
Detailed Description
Sepsis is a systemic inflammatory response to a severe infection. Despite the high incidence and societal costs of sepsis, the mechanism by which it kills remains unclear. The pathophysiology of sepsi...
Eligibility Criteria
Inclusion
- ≥ 18 years.
- Have consensus criteria for sepsis (infection plus two of four systemic inflammatory response syndrome \[SIRS\] signs \[tachycardia, tachypnea, fever or hypothermia, leukocytosis or leukopenia\]) and a known or suspected infection for SEPTIC arm.
- Patients without criteria for sepsis will be eligible for CONTROL arm. Patient must consent to have blood drawn within 24 hours of initiation of mechanical ventilation (for CONTROL arm) and 24 hours of new episode of sepsis to be eligible (for SEPTIC arm).
Exclusion
- Consent not available or declined
- Prisoner
- Died before blood collected
- Onset of sepsis more than 24 hours prior to transfer to OSUMC,mechanical ventilation greater than 24 hours
- Anticipation of less than 24 hours of mechanical ventilation by primary team
- Women who are pregnant.
Key Trial Info
Start Date :
February 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01135277
Start Date
February 1 2010
End Date
November 1 2012
Last Update
September 11 2025
Active Locations (1)
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1
The Ohio State University
Columbus, Ohio, United States, 43221