Status:
COMPLETED
Investigation of the Serotoninergic System in Multiple System Atrophy: a Positron Emission Tomography (PET) Study
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Multiple System Atrophy
Eligibility:
All Genders
30-80 years
Brief Summary
Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder of the adult associated to a poor prognosis. MSA is clinically characterized by the association of extra-pyramidal, dysautonomic,...
Eligibility Criteria
Inclusion
- Patients with Multiple system atrophy (MSA)
- MSA possible or probable
- Male and female
- Age : 30 to 80
- No cognitive impairment
- Unmodified treatment for 2 months
- Able to give informed consent
- Affiliated to social insurance
- Patients with idiopathic Parkinson's disease (IPD):
- Positive clinical criteria for IPD
- Male and female
- Age : 30 to 80
- No cognitive impairment
- Unmodified treatment for 2 months
- Able to give informed consent
- Affiliated to social insurance
- Healthy controls:
- Absence of neuropsychiatric disorder
- Male and female
- Age : 30 to 80
- Able to give informed consent
- Affiliated to social insurance
Exclusion
- Patients with Multiple system atrophy (MSA)
- Other Parkinsonian syndrome
- Dementia
- Recent intake (\< 4 weeks or 8 weeks for fluoxetine) of medication acting on 5-HT1a receptors
- History of major depression
- Contraindication to brain MRI
- Contraindication to PET
- Patients with idiopathic Parkinson's disease
- Other Parkinsonian syndrome
- Dementia
- Recent intake (\< 4 weeks or 8 weeks for fluoxetine) of medication acting on 5-HT1a receptors
- History of major depression
- Contraindication to brain MRI
- Contraindication to PET
- Healthy controls:
- Patient having a neuropsychiatric disease
- Recent intake (\< 4 weeks or 8 weeks for fluoxetine) of medication acting on 5-HT1a receptors
- History of major depression
- Contraindication to brain MRI
- Contraindication to PET
Key Trial Info
Start Date :
April 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2016
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT01136213
Start Date
April 1 2010
End Date
March 1 2016
Last Update
August 4 2017
Active Locations (3)
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1
CHU de Bordeaux
Bordeaux, France, 33076
2
CHU Limoges
Limoges, France
3
CHU de Toulouse
Toulouse, France, 31059