Status:
COMPLETED
Autonomic Nervous System and Nitric Oxide Interactions
Lead Sponsor:
Vanderbilt University
Conditions:
Endothelial Dysfunction
Eligibility:
All Genders
18-60 years
Phase:
PHASE1
Brief Summary
The investigators are interested in the role of the autonomic nervous system in the regulation of endothelial function among obese hypertensive subjects. In particular, the investigators will study ho...
Eligibility Criteria
Inclusion
- For lean healthy volunteers:
- 20 subjects (10 males and 10 females) aged 18-60 yr.
- All potential volunteers will have routine blood test to screen for hepatic, renal, and hematological abnormalities.
- Body mass index \< 25Kg/m2 .
- Female volunteers of childbearing potential will undergo HCG pregnancy test at screening and again on the study day.
- For Obese subjects with high blood pressure.
- 20 subjects (10 males and 10 females) aged 18-60 yr.
- All potential volunteers will have routine blood test to screen for hepatic, renal, and hematological abnormalities.
- Body mass index \> 30 and less than 40 Kg/m2
- \*High blood pressure (systolic=130 and diastolic = 85 mmHg)
- Female volunteers of childbearing potential will undergo serum HCG pregnancy test at screening and urine HCG pregnancy test again on the study day.
- Exclusion criteria:
- Pregnant females
- Subjects unable to give voluntary informed consent
- Subjects on anticoagulant drugs or anemic
- Subjects with a recent medical illness
- Subjects with a history of coronary heart disease
- Subjects with known kidney or liver disease
- Subjects with recent weight loss or consuming low carbohydrate diet
Exclusion
Key Trial Info
Start Date :
June 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2017
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT01137253
Start Date
June 1 2010
End Date
January 1 2017
Last Update
February 28 2018
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232