Status:
WITHDRAWN
Acetaminophen in Combination With N-Acetylcysteine (NAC) Versus Placebo in Treating Fever
Lead Sponsor:
Columbia University
Conditions:
Liver Failure
Liver Failure, Acute
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The purpose of this study is to compare the efficacy of the an N-acetyl-p-aminophenol (APAP, also known as acetaminophen) and N-acetylcysteine (NAC) combination versus an APAP-placebo combination as a...
Detailed Description
N-acetyl-p-aminophenol (APAP), or more commonly known as acetaminophen in the United States, accounts for more overdose and overdose deaths in the United States and United Kingdom than any other pharm...
Eligibility Criteria
Inclusion
- adults aged 18 to 75 years old
- admitted to an inpatient unit at Columbia-Presbyterian Medical Center
- fever defined as an oral temperature of 38.5°C
Exclusion
- if oral temperature cannot be obtained
- abnormal aminotransferase levels
- prior adverse reaction to acetaminophen or N-acetylcysteine
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01137591
Start Date
April 1 2009
Last Update
March 5 2015
Active Locations (1)
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1
Columbia University Medical Center
New York, New York, United States, 10032