Status:
WITHDRAWN
Bacterial and Host Genetic Risk Factors in Acute Pyelonephritis
Lead Sponsor:
Hans Pohl
Conditions:
Vesicoureteral Reflux
Eligibility:
All Genders
2-24 years
Brief Summary
No single host or pathogen trait identified by previous research can be correlated with all cases of childhood acute pyelonephritis or APN (i.e., kidney/upper urinary tract infections) and APN-associa...
Detailed Description
Urinary tract infections (UTIs) are the most common serious bacterial infections in young children, with acute pyelonephritis or APN (i.e., kidney/upper urinary tract infections) and APN-associated re...
Eligibility Criteria
Inclusion
- Infants admitted to the inpatient ward at Children's National Medical Center for the treatment of a febrile urinary tract infection (see definitions) will be screened for inclusion into the research protocol.
- UTIF: A UTIF will require the presence of
- (1) fever and/or symptoms consistent with UTI,
- (2) pyuria based on urinalysis, and
- (3) culture-proven infection with a single organism. Specifically, the study definition of UTIF will require:
- Fever: A documented temperature of at least 100.4 °F or 38°C, measured anywhere on the body either at home or at doctor's office.
- Positive dipstick analysis: Pyuria on urinalysis (\>10 WBC/mm3 (uncentrifuged specimen) OR \>5 WBC/hpf (centrifuged specimen), OR \>1+ leukocyte esterase on dipstick).
- Culture documentation of UTI: Evidence of bacteria (\>5 x 104 CFU/mL (catheterized or suprapubic aspiration urine specimen). Bag collected specimens will not be acceptable
Exclusion
- Infants who do not conform to the above inclusion criteria and who have co-morbidities such as duplication abnormalities, diabetes mellitus, over weight status, anatomical defects of the urinary tract and neuropathic bladder dysfunction.
Key Trial Info
Start Date :
November 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2016
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01137929
Start Date
November 1 2014
End Date
November 1 2016
Last Update
October 2 2014
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