Status:

COMPLETED

Cardiorenal Interactions During Treatment of Acute Decompensated Heart Failure: Diuretics Versus Ultrafiltration

Lead Sponsor:

University Hospital, Ghent

Conditions:

Acute Decompensated Heart Failure

Eligibility:

All Genders

18+ years

Phase:

PHASE3

Brief Summary

The CRUF trial is a prospective randomized monocentric trial comparing different impact of diuretics versus ultrafiltration on renal congestion, plasma refill rate, echocardiographic filling pressures...

Eligibility Criteria

Inclusion

  • \>18 years old
  • Severe systolic heart failure with ejection fraction \<40%
  • And Hospitalisation for decompensated heart failure
  • And New York Heart Association (NYHA) III or IV
  • And 1 of the following:
  • Jugular vein distension\>6cm
  • Tissue Doppler mitral annulus lateral\>12 or medial\>15
  • Chest X-ray: pulmonary edema or pleural effusion

Exclusion

  • Need for inotropic or vasopressive agents
  • Use of intravenous (IV) contrast media
  • Acute coronary syndrome
  • Need of dialysis
  • Severe co-morbidity
  • Contra-indications for anticoagulation
  • Pregnancy

Key Trial Info

Start Date :

February 1 2010

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

December 1 2011

Estimated Enrollment :

1 Patients enrolled

Trial Details

Trial ID

NCT01138683

Start Date

February 1 2010

End Date

December 1 2011

Last Update

January 10 2012

Active Locations (1)

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1

University Hospital Ghent

Ghent, Belgium