Status:
UNKNOWN
Sub-total Parathyroidectomy Reduces Vascular Calcification in Haemodialysis Patients
Lead Sponsor:
Guangdong Provincial People's Hospital
Conditions:
Hemodialysis
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The aim of this study was to evaluate whether successful sub-total parathyroidectomy retards cardiovascular calcification in patients with hemodialysis and to investigate the mechanism .
Detailed Description
Hyperparathyroidism (PHPT) in patients with end-stage renal disease have been shown to have an increased morbidity and mortality mainly due to cardiovascular disease. The precise mechanism of cardiova...
Eligibility Criteria
Inclusion
- The patients receiving hemodialysis treatment, with elevated intact parathyroid hormone (iPTH) levels \> 800pg/ml on two or more occasions.
- Patients with parathyroid nodular or diffuse hyperplasia identified by ultrasound imaging or radioisotope scan.
Exclusion
- Patients with significant background valvular heart disease
- Patients who are unfit for general anaesthesia
- Patients with acute myocardial infarction within recent two months
- Patients with poor general condition
- Patients with plans for living related kidney transplant within 1 year
- Patients with previous history of parathyroidectomy
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2011
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01140490
Start Date
January 1 2009
End Date
December 1 2011
Last Update
March 11 2011
Active Locations (1)
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1
Guangdong General Hospital
Guangzhou, Guangdong, China, 510080