Status:
COMPLETED
Real-world Effectiveness of Combination Therapy in Asthma
Lead Sponsor:
Research in Real-Life Ltd
Collaborating Sponsors:
Mundipharma Research Limited
Conditions:
Asthma
Eligibility:
All Genders
4-80 years
Brief Summary
This study will evaluate and compare the effectiveness of asthma management in patients with evidence of persistent asthma following a switch in asthma therapy to combination inhaled glucocorticostero...
Detailed Description
Current asthma guidelines in the UK are underpinned by evidence derived from randomised controlled trials (RCTs). Although RCT data are considered the gold standard, patients recruited to asthma RCTs ...
Eligibility Criteria
Inclusion
- Aged: 4-80 years: Paediatric cohort (aged 4-11 years); Adult cohort (aged 12-69 years); Elderly cohort (aged 70-80 years.
- Evidence of asthma: i.e. a diagnostic code of asthma or ≥2 prescriptions for asthma at different points in time during the prior year, including one ICS prescription.
- Be on current asthma therapy: i.e. ≥1 asthma prescriptions in the prior year, and at least 1 other asthma prescription during the same period.
- Have at least one year of up-to-standard (UTS) baseline data (prior to the IPD) and at least one year of UTS outcome data (following the IPD).
Exclusion
- Diagnostic read code for chronic respiratory disease (including COPD) at any time
- On maintenance oral steroid therapy at baseline
- Any patients receiving a combination inhaler in addition to their separate ICS inhaler in the baseline year.
Key Trial Info
Start Date :
January 1 2001
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
815377 Patients enrolled
Trial Details
Trial ID
NCT01141465
Start Date
January 1 2001
End Date
February 1 2010
Last Update
June 10 2010
Active Locations (1)
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1
General Practice Research Database
London, United Kingdom, SW8 5NQ