Status:
UNKNOWN
NADPH Oxidase Polymorphisms in Obstructive Sleep Apnea Syndrome (OSAS)
Lead Sponsor:
Sociedad Española de Neumología y Cirugía Torácica
Collaborating Sponsors:
Spanish Research Center for Respiratory Diseases
Conditions:
Sleep Apnea Syndrome
Oxidative Stress
Eligibility:
All Genders
18+ years
Brief Summary
Obstructive Sleep Apnea (OSA) is associated with increased oxidative stress. The major sources of Reactive Oxygen Species (ROS) in the vasculature are the NADPH oxidases. Several polymorphisms related...
Detailed Description
DESIGN: CASE-CONTROL STUDY METHODS: We are going to determine the A-930G and C242T p22phox genotypes in patients with OSA and healthy subjects recruited from sleep unit of Son Dureta University Hospit...
Eligibility Criteria
Inclusion
- Polyysomnografic study with Apnoea/Hypoapnoea Index higher to 10 in patients and lower in controls.
Exclusion
- chronic obstructive pulmonary disease, liver cirrhosis, thyroid dysfunction, rheumatoid arthritis, chronic renal failure and/or psychiatric disorders.
Key Trial Info
Start Date :
Trial Type :
OBSERVATIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01141829
Last Update
June 11 2010
Active Locations (1)
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1
Hospital Universitario Son Dureta
Palma de Mallorca, Balearic Islands, Spain, 07014