Status:
COMPLETED
Early Selective TAE to Severely Bleeding Peptic Ulcers After Their Initial Endoscopic Hemostasis
Lead Sponsor:
Chinese University of Hong Kong
Collaborating Sponsors:
King Chulalongkorn Memorial Hospital
Conditions:
Bleeding
Peptic Ulcer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of this study is to determine if early angiographic embolization can forestall recurrent bleeding in selected high risk ulcers after their initial endoscopic control; to validate prospectively...
Detailed Description
Endoscopic therapy is now the treatment of choice in patients with actively bleeding peptic ulcers and ulcers with non-bleeding visible vessels. Following endoscopic control of bleeding, we showed tha...
Eligibility Criteria
Inclusion
- Actively bleeding peptic ulcers (Forrest I), NBVV or Forrest IIa ulcer,
- Successful endoscopic hemostasis by combination treatment of injected epinephrine followed by either 3.2mm heat probe 30J (4 continuous pulses) or hemo-clipping (at least 2 clips) And one of the followings
- Spurting hemorrhage during endoscopy;
- Ulcer \>= 2 cm is determined by an opened biopsy forceps;
- Hb on admission of \< 9 g/dl; or
- Hypotension prior to endoscopy defined by SBP of \<90 mmHg AND HR of \>110 bmp
Exclusion
- \-
Key Trial Info
Start Date :
January 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2014
Estimated Enrollment :
258 Patients enrolled
Trial Details
Trial ID
NCT01142180
Start Date
January 1 2010
End Date
July 1 2014
Last Update
July 18 2018
Active Locations (1)
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1
Endoscopy Centre, Prince of Wales Hospital
Hong Kong, China