Status:
COMPLETED
Effect of IV and Oral Esomeprazole in Prevention of Recurrent Bleeding From Peptic Ulcers After Endoscopic Therapy
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Peptic Ulcer
Bleeding
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The investigators previously showed that the use of a high-dose intravenous PPI regimen after endoscopic control of bleeding from peptic ulcers reduced rate of recurrent bleeding, decreased the need f...
Detailed Description
The investigators previously showed that the use of a high-dose intravenous PPI regimen after endoscopic control of bleeding from peptic ulcers reduced rate of recurrent bleeding, decreased the need f...
Eligibility Criteria
Inclusion
- Age ≥ 18
- Confirmed ulcer bleeding with Forrest Ia, Ib, IIa, IIb
- Endoscopic hemostasis achieved
- Informed consent obtained
Exclusion
- No consent
- Forrest II c, III (clear ulcer base/flat spot and no active bleeding, i.e., minimal risk for rebleeding)
- Unsuccessful endoscopic treatment (i.e., injection and/or thermal coagulation for the initial bleeding) or severe bleeding that immediate surgery is indicated
- Moribund patients in whom active treatment of any form is not considered.
- Polytrauma, severe injury, unconsciousness, burns, or need for continuous artificial ventilation
- Upper GI malignancy or disseminated malignant disease
- Esophageal varices
- A Mallory-Weiss lesion
- Phenytoin or theophylline treatment
- Uses of PPI or H2RAs within 3 days of admission, including uses at Emergency Department N.B. Usage of aspirin or NSAID is not an exclusion criteria.
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2014
Estimated Enrollment :
263 Patients enrolled
Trial Details
Trial ID
NCT01142245
Start Date
January 1 2008
End Date
July 1 2014
Last Update
August 13 2015
Active Locations (2)
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1
Endoscopy Centre
Hong Kong, China, 852
2
Endoscopy Center in Prince of Wales Hospital
Hong Kong (sar), China