Status:
WITHDRAWN
Physiology of Volition Studied With Nerve Block
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Healthy Volunteers
Eligibility:
All Genders
18-55 years
Brief Summary
Background: \- The experience of volition that accompanies voluntary movement can be divided into the sense of will, or deciding to move, and the sense of agency, or feeling that the movement just ma...
Detailed Description
OBJECTIVE: The primary objective of this study is to determine the brain regions responsible for the sense of volition and the associated sense of agency. Nerve blocks will be used to interfere with ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Healthy right-handed subjects ranging from 18 to 55 will be included. All subjects should have a valid Clinical Center Medical Record Number.
- EXCLUSION CRITERIA:
- Healthy subjects younger than 18 years and older than 55 will be excluded.
- Subjects with MRI findings consistent with organic brain lesions such as brain tumors, stroke, trauma or AVMs will be excluded.
- Subjects with active significant medical or neurological disorders, or active Axis I psychiatric disorders, or requiring continuous treatment with drugs that affect the central nervous system will be excluded.
- We will not include pregnant women because safety of high magnetic field to fetus is not established.
- Subjects allergic to local anesthetics such as bupivacaine will be excluded.
- Subjects unable to have an MRI due to claustrophobia or contraindications to MR scanning will be excluded.
- Subjects who are left-handed will be excluded.
- Subjects will be excluded who are taking anticoagulant or antiplatelet medications such as warfarin, heparin, clopidogrel, ticlopidine, or fondiparinux, or vitamin E in amounts greater than 1600 IU per day.
- If subjects are taking daily aspirin therapy, this must be held for 7 days prior to the nerve block. If subjects are taking daily NSAIDs, these must be held for 12 hours prior to the nerve block. If these medications cannot be held for these periods, the subject will be excluded.
Exclusion
Key Trial Info
Start Date :
June 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 4 2012
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01143506
Start Date
June 1 2010
End Date
January 4 2012
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892