Status:
COMPLETED
Evaluation of Skin, Colonic, and Oral Microbiome and Effect of Time and Antibiotic Treatment on Organism Diversity at Each Site
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
BMI
General Demographics Characteristics
Eligibility:
All Genders
18-100 years
Brief Summary
Background: * Most studies of infectious agents have focused on specific microbes, such as human papillomaviruses and cervical cancer, and the hepatitis B and C virus and liver cancer. The skin and m...
Detailed Description
The study of infectious agents and their role in disease is not new. Most efforts in this area have focused on specific agents, such as human papillomaviruses and cervical cancer, Helicobacter pylori ...
Eligibility Criteria
Inclusion
- ELIGIBILITY CRITERIA:
- Individuals who meet the age criteria of 18 years and older and are interested in the study will be asked to provide written informed consent. Participants must be willing to reside in the study area for the study duration (6 months). Those individuals with any known medical conditions that may limit life expectancy in the short term (including but not limited to: congestive heart failure, renal failure, prior malignancy, or any other chronic disease that limits functional status to the extent that the individual cannot perform light work or the usual activities of daily self care) are ineligible for inclusion in the study. Female participants must not be pregnant.
- Individuals who report recent antibiotic use will be deferred and enrolled after they have been at least 6 weeks without antibiotic use.
- In Hojancha, region of Guanacaste, Costa Rica, where our study will be conducted, a population based census was completed in March 2009 and will serve as the basis for enrollment, allowing for recruitment of a representative sample of the population. The same census was used to identify participants for another study in the same area. Therefore, because we will use the same census, we will exclude participants that were enrolled in the other study. Eligible participants must be willing to return for one follow-up visit: 6 months after the initial enrollment visit and willing to allow submission of blood for assays of serum immune markers, host genetic susceptibility and environmental factors, and to provide consent for use of the specimens.
Exclusion
Key Trial Info
Start Date :
November 20 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT01143571
Start Date
November 20 2009
Last Update
June 11 2020
Active Locations (1)
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1
Proyecto Epidemiologico in Hohancha
Hojancha, Costa Rica